Chaochang Ming, Duohang Bi, Hongtao Tian, Weijian Liu, Haitao Li, Yuxiang Hu, Zhenyu Song, Dongdong Xu, Hao Xu, Hongyan Li, Shenghui Lan, Weihua Xu, Wei Chen, Qiong Li, Jiawei Feng, Qianqian Cao, Xiaoyang Wang, Panlong Fan, Jintao Zhu, Yu Wei, Chaoge Ming, Zhipeng Dai, Yijing Liu, Wei Tong
Targeting senescent macrophages via MNs@De attenuates OA progression without requiring intra-articular injections or increasing systemic drug exposure. Microneedle-mediated denosumab delivery offers a minimally invasive, localized therapeutic strategy for OA.