◆ International Journal of Biological Sciences2026-01-15· Glycolysis
Delactylase effects of SIRT3 on a positive feedback loop involving the RUNX1-glycolysis-histone lactylation in diabetic kidney disease
Siman Shen, Chen Chu Ying, Xinglin Fu, Xiaobian Zeng, Xiuli Guo, Han Wu, Liangqing Zhang, Li Xu
原始摘要（英文原文）· Original abstract
Thus, the study links RUNX1-mediated glycolysis to SIRT3-mediated histonelactylation epigenetic reprogramming in promoting the fibrotic process, providing better understanding of epigenetic regulation of DKD pathogenesis, and new therapeutic strategy for DKD.
Delactylase effects of SIRT3 on a positive feedback loop involving the RUNX1-glycolysis-histone lactylation in diabetic kidney disease — 科研速览 Science Skim