Xue Zhou, Xian Fu, Yi-Wen Meng, Ping Dai, Qing Jiang, Hou-Hua Yin, Qing-Jin Pan, Ai-Zhi Lin, Kai-Di Ni, Ziguo Luo, Ru-Yu Liang, Yi-Yu Chen, Hai‐Xin Yuan, Jun-Yan Liu
transcriptional cascade, thereby promoting mitophagy and restoring mitochondrial homeostasis. Functional assays supported that this pathway plays a pivotal role in protecting RTECs from oxidative damage. Collectively, these findings uncover a previously unrecognized role of CDC42 in AKI pathogenesis and highlight CDC42 inhibition as a promising therapeutic strategy for mitigating mitochondrial damage and improving renal outcomes.