Guangmin Song, Hongli Li, Man Zhang, Yun Li, Xinyi Tao, Andi Wang, Jianqi Wang, Boris Novakovic, Richard D. Cannon, Richard R.S. Saffery, Hongbo Qi, Hua Zhang, Xiaobo Zhou
, excessive administration of KYN in pregnant mice increases the rate of embryo resorption, whereas pharmacological inhibition of AHR partially attenuates cGAS-STING pathway activation in dMφs and ameliorates fetal loss in an abortion-prone mouse model. Collectively, our findings describe a pivotal role for the AHR/CISH/ATP6V1A axis in orchestrating immune dysfunction within the decidua that may contribute to URPL, which sheds new light on the potential pathogenesis of URPL and paves the way for improving pregnancy outcomes.