Yaning Chen, Sai Zhu, Li-Jiao Sun, Rongrong Zhou, Rui Zheng, Xiaofeng Li, Liang‐yun Li, Sijin Sun, Yu-Xin Zhao, Cheng Huang, Xiao‐Ming Meng, Lei Zhang, Xiongwen Lv, Hua Wang, Xin Chen, Jun Li
N 6 -methyladenosine (m 6 A), a well-known adenosine modification with newly recognized epigenetic functions, reportedly participates in the development of diverse liver diseases.Methyltransferases and demethylases, commonly referred to as "writers" and "erasers", respectively, play crucial roles in maintaining the balance of m 6 A modification.In liver disease research specifically, the functioning of these enzymes has piqued significant interest, revealing new perspectives on molecular pathogenic mechanisms.Writer proteins collaborate with co-factors to install m 6 A modification on RNA, while eraser proteins, exemplified by Fto and Alkbh5, remove modifications via different mechanisms.In liver diseases, the two are not simply antagonistic, but rather act jointly to affect disease progression.By focusing this review on the mechanisms of methyltransferases and demethylases in various liver diseases, we seek to enhance comprehension of m 6 A modification's role and support the advancement of related research and treatment strategies.