◆ International Journal of Biological Sciences2025-10-01· Myofibroblast
Cardiac fibroblast-derived IGFBP6 orchestrates cardiac remodeling by coupling the EGR1-MFAP4 axis
Shaopeng Cheng, Yilin Wang, Kunsheng Li, Xiaoting Wu, Qianwen Zhao, Tingting Tong, Jian Shi, Y. Xue, Jie Yang, Dongjin Wang
原始摘要（英文原文）· Original abstract
Our study identifies fibroblast-derived IGFBP6 as a novel regulator of cardiac fibrosis through the EGR1-MFAP4 signaling axis, driving myofibroblasts differentiation and adverse remodeling. Targeting this pathway may offer therapeutic potential for cardiac remodeling disorders.