Abnormal Expression of Transcription Factor IIIA in Tumors and Target Therapy Potential Application for Transcription Factor IIIA

Transcription factor III a (TFIIIA), as one of the specific transcription factor members of RNA polymerase III, plays an important role in guiding the transcription of 5S rRNA genes by RNA polymerase III. This article elaborates on the special structure and function of TFIIIA, and introduces the synergistic effect of homologous transcription factors TFIIIB and TFIIIC in the process of 5S rRNA gene transcription guided by RNA polymerase III. It also discusses the relationship between RNA polymerase III transcription activity and the product 5SrRNA and the occurrence and development of tumors. The abnormal expression of most transcription factors is involved in the occurrence and development of various cancers, and 20% of the oncogenes discovered are transcription factors. In order to explore the transcription factor TFIIIA as a tumor therapy target, this article probe the strategy in which transcription factors are used as tumor therapy targets based on discussing TFIIIA structure and function, including its expression and degradation, interaction with cofactors/proteins, and dynamic changes in its binding to DNA.