Isothermal Kinetic Study of Polyvinylpyrrolidone Thermal Degradation Using Thermogravimetric Analysis

Polyvinylpyrrolidone (PVP) is a widely used water-soluble polymer with applications in pharmaceuticals, cosmetics, adhesives, and medical devices. Despite its versatility, the thermal stability of PVP remains a concern during processing and high-temperature applications, where degradation can compromise performance and safety. This study aimed to investigate the kinetic parameters of PVP thermal degradation using isothermal thermogravimetric analysis (TGA) over a temperature range of 30–800 °C. PVP samples were analyzed under a nitrogen atmosphere, and weight loss was recorded over time. Kinetic parameters, including activation energy (Ea) and pre-exponential factor (A), were determined, and molecular weight changes were evaluated via gel permeation chromatography. Results indicated multi-stage degradation with increasing Ea at higher temperatures, consistent with backbone scission and pyrrolidone ring decomposition. Molecular weight decreased progressively, and polydispersity increased, reflecting chain fragmentation. The study provides accurate isothermal kinetic data, contributing to better prediction of PVP behavior under thermal stress and guiding the design of thermally stable formulations