Vinicius de Lima Lovadini, Fernando Deungaro De Mendonça, Patrícia Michelassi Carrinho Aureliano, Ana Paula De Lima, Evelise Pires Cogo Simão, Vanessa Dias de Oliveira Justi, Livia Moreira da Silva, Ana Elisa Pereira Da Silva, Tharinne Oliveira Silva Cavalheiro, Valter Mariano dos Santos Junior, Nicezia Vilela Junqueira Franqueiro, Luana Biancardini, Nínive Xisto De Souza, Thaisa Silva De Sousa
Objective: to map and synthesize evidence on the role of Primary Health Care (PHC) in surveillance, early diagnosis, clinical management, isolation guidance, referral, health education, and professional training related to mpox, with emphasis on the Brazilian context. Method: exploratory scoping review developed in accordance with Joanna Briggs Institute guidance and structured according to PRISMA-ScR. Searches were carried out in national and international databases and complemented by gray literature, with an initial retrieval of 1,000 records and final inclusion of 80 studies and documents. Results: only four studies directly addressed Brazil, revealing a major gap regarding the role of the Family Health Strategy. The literature indicates that PHC can support early detection, triage, reporting, isolation guidance, outpatient management of mild cases, health education, and coordination with other levels of care; however, important barriers persist, including limited access to molecular diagnosis, lack of PHC-specific protocols, stigma, territorial inequalities, and insufficient training. Conclusion: mpox requires more explicit incorporation into Brazilian PHC workflows, with stronger surveillance, continuing education, integration with referral services, and development of tailored operational protocols.