S. Tamana, C. Yiangou, K. Orphanou, M. Xenophontos, P. L. Papasavva, C. Bernabe, M. Roos, D. Wijnbergen, M. G. Kersloot, R. Cornet, A. Minaidou, C. Stephanou, S. Chatzimatthaiou, A. Landi, V. Giannuzzi, F. Bonifazi, C. W. Lederer, P. Kountouris
Haemoglobinopathy registries support research and outcome monitoring. Still, reuse is limited due to heterogeneous structures, registry-specific coding, and incomplete semantic representation. We designed and implemented a FAIRification workflow for the INHERENT haemoglobinopathy platform, an international genotype-phenotype registry, as part of the HemaFAIR project. The workflow was extended to the Cyprus Haemoglobinopathy Patient Registry to demonstrate its applicability across a second registry. Source data and metadata were transformed through two independent but complementary harmonisation branches executed in parallel: one producing an OMOP CDM representation, and the other generating a CARE-SM representation. The workflow generated graph-based semantic resources, predefined query services, public aggregate dashboards, and application programming interface (API) endpoints. Registry metadata were published through the European Rare Disease Registry Infrastructure and a FAIR Data Point. These outputs support findability, interoperable analysis and controlled reuse while preserving existing governance over patient-level data.