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◇ medRxiv2026-09-16· ophthalmology

Task-Specific Quality Gating for Retinal Optical Coherence Tomography B-Scans: Learned Representations Over Scalar Metrics in Choroid Segmentation

A. Hiras, A. Jayaraman, A. Gadari, A. S. Mankumare, A. Mynampati, J. K. Chhablani, S. C. Bollepalli, K. K. Vupparaboina

原始摘要(英文原文)· Original abstract
Automated segmentation of Optical Coherence Tomography (OCT) images is a critical component of structural biomarker extraction for retinal diagnostics. Deep learning models achieve state-of-the-art performance on controlled datasets, yet exhibit unpredictable failures on real-world data. Current quality gates rely on device-reported scan quality scores, which have been shown to be unreliable predictors of segmentation performance. We define scan quality in a task-specific sense, that is, whether a given B-scan will yield a reliable segmentation from a particular trained model. Under this definition, we systematically evaluate No-Reference Image Quality Assessment (NR-IQA) metrics, general-purpose pretrained representations, and domain-specific pretrained representations as alternative quality gates. We use choroid segmentation as the prototype task, with a dataset of 6,076 OCT B-scans from 80 subjects. These quality gate candidates are evaluated at three levels: scalar metrics (BRISQUE, NIQE, PIQE, SNR, PSNR), supervised linear probing, and unsupervised partitioning (K-Means) of feature vectors and learned representations. All scalar NR-IQA metrics proved inadequate (|r| < 0.20). General-purpose pretrained representations (EfficientNet-B0, ResNet-50, ViT-B/16) outperform NR-IQA, achieving ROC-AUC up to 0.77, indicating that learned representations are better suited to task-specific quality gating than hand-crafted scalar statistics. Retinal foundation models (FMs) further improve performance: RETFound, an OCT-specific FM, achieves ROC-AUC of approximately 0.81. Unsupervised K-Means partitioning of the embeddings recovers the same hierarchy geometrically: only the two retinal foundation models produce quality-aligned clusters that exceed a patient-level permutation null, while NR-IQA and general-purpose pretrained feature spaces do not, suggesting that domain-specific pretraining provides an additional benefit beyond general-purpose learned representations.
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