Hippocampal CA2 Inhibition Disrupts Prefrontal and Thalamic Connectivity

Disturbances in the CA2-subfield of the hippocampus have been associated with symptoms of psychiatric disorders, including impaired social behavior. Using chemogenetic inhibition during functional ultrasound imaging, we found that dorsal CA2 pyramidal neurons broadly control prefrontal and thalamic communication, in addition to hippocampal and thalamic activity. Correspondingly, chronic CA2 inhibition altered social interaction.