Gerardo Parra, Klara Szilagyi, Yael Braverman, Devorah Kranz, E Martina Bebin, Raphael A Bernier, Jonathan A Bernstein, Elizabeth Berry-Kravis, Joseph D Buxbaum, Katarzyna Chawarska, Emma E Condy, Laura Cornelissen, Geraldine Dawson, Abigail Dickinson, James Dziura, Charis Eng, Susan Faja, Jennifer H Foss-Feig, Jeffrey P Gavornik, Antonio Y Hardan, Ellen Hanson, Shafali Jeste, Linnea Joffe-Nelson, Alexander Kolevzon, Darcy A Kreuger, Balu Krishnan, Robert Law, David N Lieberman, Claire MacKay, Julian A Martinez-Agosto, Adam J Naples, Charles A Nelson, Hope Northrup, Ernest Pedapati, Annapurna Poduri, Vineet Punia, Rajsekar R Rajaraman, David M Ritter, Celine Saulnier, Frederick Shic, Latha Valluripalli Soorya, Catherine A Sugar, Kyle E Takach, Audrey Thurm, Sara J Webb, Kimberly Wiltrout, Damla Şentürk, Stephanie Jones, Michela Fagiolini, James C McPartland, Mustafa Sahin, April R Levin
Transient beta events (TBE) during electroencephalography (EEG) reflect thalamocortical activity, bridging genotype to phenotype and impacting sensory responsivity. Compared to typically developing controls, we found elevated TBE rate in some children with idiopathic Autism Spectrum Disorder (ASD) and a majority of children with Phelan-McDermid Syndrome, Rett Syndrome, and SYNGAP1 -related disorder. TBE rate thus offers promise as a stratification biomarker with divergent and convergent properties across ASD and neurogenetic conditions, respectively.