◆ American Journal of Cancer Research2026-01-01· Pyroptosis
Endogenous HMGB1 regulates GSDME-mediated pyroptosis via ROS/ERK1/2/caspase-3/GSDME signaling in neuroblastoma: Am J Cancer Res. 2023; 13(2): 436-451
Chen-Ying Fan, Fang-Hua Ye, Min Peng, Jiajia Dong, Wenwen Chai, Wenjun Deng, Hui Zhang, Liangchun Yang
原始摘要（英文原文）· Original abstract
, a ROS agonist) and EGF (an ERK agonist) promoted the cleavage of GSDME and caspase-3 in DDP or VP16 treatment cells, both of which were inhibited by HMGB1 knockdown. Importantly, these data were further supported by the in vivo experiment. Our study suggests that HMGB1 is a novel regulator of pyroptosis via the ROS/ERK1/2/caspase-3/GSDME pathway and a potential drug target for therapeutic interventions in neuroblastoma.