Dejen Kahsay Asgedom, Fentahun Bikale Kebede, Simachew Getaneh Endalamew, Bewuketu Terefe, Solomon Keflie Assefa, Etsay Woldu Anbesu
Overweight and obesity remain major global public health challenges, particularly among children under five years of age in low- and middle-income countries (LMICs). This study aimed to assess the pooled prevalence of overweight/obesity and its associated factors among children aged 6-59 months in 46 LMICs. We used the most recent nationally representative demographic and health surveys (2015-2024) from forty-six LMICs. A total of 393,638 weighted samples of children aged 6-59 months were included. Childhood overweight and obesity were defined as weight-for-height greater than two and three standard deviations above the WHO reference population median, respectively. Multilevel log-binomial regression models were employed. An adjusted risk ratio (RR) with a 95% confidence interval (CI) was used to select variables that had a significant association with childhood overweight/obesity. A p value < 0.05 was used to declare statistical significance. The data were analyzed with R software (version 4.5.1). The pooled prevalence of overweight/obesity was 3% (95% CI: 2.44, 3.58), with significant regional variation ranging from 1.62% in West Africa to 10% in the Europe and Central Asia (95% CI: 5.26, 17.84). Male sex (RR = 1.07, 95% CI: 1.03, 1.11), larger-than-average birth size (RR = 1.66, 95% CI: 1.54, 1.78), facility delivery (RR = 1.20, 95% CI: 1.13, 1.27), maternal smoking (RR = 1.61, 95% CI: 1.38, 1.87), maternal overweighed/obesity (RR = 2.37, 95% CI: 2.19-2.56), media exposure (RR = 1.05, 95% CI: 1.01, 1.10), and rich (RR = 1.10, 95% CI: 1.04, 1.16) household wealth were factors associated with increased risk. Children aged 24-59 months had lower risk compared to those aged 6-23 months. Protective factors included current breastfeeding (RR = 0.91, 95% CI: 0.87, 0.95), interpregnancy intervals 18-23 months (RR = 0.77, 95% CI: 0.71, 0.83), and ≥ 24 months (RR = 0.87 95% CI: 0.83, 0.91), and multiple births (RR = 0.67, 95% CI: 0.57, 0.79). Contextually, children in medium-human development index (HDI) (RR = 1.80, 95% CI: 1.62, 2.00) and higher-HDI countries (RR = 3.57, 95% CI: 3.00, 4.24) had elevated risk. Compared to West Africa, all other regions showed significantly higher risk, with Europe & Central Asia demonstrated the strongest association (RR = 3.37, 95% CI: 2.90, 3.91). The pooled prevalence of overweight/obesity among under-five children in LMICs is relatively low compared to high-income nations, yet substantial regional variation exists. Male sex, larger size at birth, maternal smoking, maternal overweight/obesity, higher household wealth quantiles and higher-HDI were associated with increased risk of childhood overweight/obesity, whereas current breastfeeding and longer interpregnancy intervals were protective. These findings highlight the importance of close monitoring of the problem and region-specific interventions targeting modifiable risk factors.