Priyanka Kumari, Diksha Ranga, Pooja Yadav, Vandana Saini, Ajit Kumar
Neisseria meningitidis remains a serious global health threat due to rapid progression, high mortality and rising antibiotic resistance. FabF, a key enzyme in the bacterial fatty acid synthesis (FAS II) pathway, is a promising target for new antimicrobials. A 3D model of FabF was constructed and validated and 2,583 marine natural compounds were screened for drug-likeness and ADMET properties. Molecular docking of 241 selected compounds identified three candidates with stronger binding affinity than minocycline. Compounds CMNPD5392, CMNPD14910 and CMNPD14926 showed promising interactions, indicating potential as FabF-targeted therapeutics.