Lorenzo Giunco, David Hernández-Hernández, María Yanira Ortega-González
Male genital lymphedema is a rare condition characterized by progressive enlargement of the scrotal and penile tissues. It is associated with substantial physical and psychological morbidity, frequently impairing urinary and sexual function, hygiene, and ambulation. Genital lymphedema may result from secondary lymphatic obstruction to infectious, inflammatory, neoplastic, congenital, or iatrogenic causes. Despite its clinical impact, no standardized diagnostic or therapeutic algorithm has been established to date. Herein, we present our diagnostic approach and describe a surgical technique involving excision of penoscrotal lymphedematous tissue followed by genital reconstruction using local flaps. The management of massive genital lymphedema remains surgically challenging, with multiple reconstructive options available depending on the extent of the disease and patient characteristics. Reconstructive surgery is generally associated with favorable functional and aesthetic outcomes, leading to significant improvements in quality of life.