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◆ Computer Science Engineering and Technology2026-02-05· Antibiotics

Evaluating the Impact of Antibiotics on Childhood Immunity A WASPAS Analysis of Immune System Development and Long-Term Health Effects

Sathishkumar Mani

原始摘要(英文原文)· Original abstract
The impact of antibiotics on childhood immunity has been a subject of significant research and ongoing debate in medical science. Antibiotics, while essential for treating bacterial infections and saving lives, have raised concerns regarding their potential influence on the developing immune system of children. This study explores the complex relationship between antibiotic use and immune development, highlighting both beneficial therapeutic effects and unintended negative consequences. The widespread prescription of antibiotics in childhood has contributed to the emergence of antibiotic-resistant bacteria, posing a serious public health challenge. Resistant infections are often harder to treat, resulting in longer illness durations and increased healthcare costs. Childhood represents a critical period for immune system development, during which early exposure to microorganisms helps shape immune responses later in life. Antibiotics can disrupt these natural microbial interactions by altering the composition of the gut microbiota, potentially reducing microbial diversity and affecting immune function. Such disruptions may increase susceptibility to allergies, infections, and immune-related disorders in later stages of life. To assess the impact of antibiotics on childhood immunity, the Weighted Aggregated Sum Product Assessment (WASPAS) method was applied. These multi-criteria decision-making approach assigns weights to relevant factors and aggregates scores to evaluate outcomes effectively. The analysis revealed variations among children, with Child 4 ranking highest in antibiotic impact on immunity, while Child 5 ranked lowest. These findings demonstrate individual differences in immune response and highlight the importance of cautious antibiotic use.
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