Konstantinos Chaidas, Artemis Zarkadi, Nikolaos Tepelenis, Sotirios Papouliakos
Primary Burkitt lymphoma (BL) of the maxillary sinus is rare, particularly in immunocompetent adults, and only a few cases have been reported in the literature. Its clinical presentation may mimic benign conditions, such as chronic rhinosinusitis or neuropathic facial pain, potentially resulting in diagnostic delay. We present the case of a 38-year-old male with a five-month history of isolated left-sided facial pain. Comprehensive clinical, radiological, and histopathological evaluation established the diagnosis of BL, and the patient subsequently received systemic chemotherapy. This case highlights the importance of considering BL in the differential diagnosis of persistent or atypical sinonasal symptoms, particularly those unresponsive to empirical treatment. Prompt biopsy and histopathological and immunohistochemical evaluation are essential for establishing the diagnosis and initiating appropriate treatment without delay.