Development of a Chitosan-Based Wound Dressing from Shrimp Shells Incorporated with Ethanol Extracts of Fruit Peels for Inhibiting Staphylococcus aureus and Staphylococcus epidermidis Infections.

BACKGROUND: Bacterial infections caused by Staphylococcus aureus and Staphylococcus epidermidis continue to pose a significant challenge to global healthcare. To assess its antibacterial efficacy, this study aimed to develop a wound dressing composed of shrimp shell-derived chitosan combined with extracts from fruit peels, specifically tangerine, mangosteen, and banana peel. METHODS: Bioactive compounds were extracted using ethanol, and the minimum inhibitory concentration (MIC) against the bacteria was determined. RESULTS: Among the extracts tested, mangosteen peel demonstrated the highest efficacy (MIC = 0.39 mg/mL for S. epidermidis) compared to tangerine and banana peels. Evaluation of the developed wound dressings revealed that those containing mangosteen peel extract exhibited the largest bacterial inhibition zones. CONCLUSIONS: These findings highlight the potential of agricultural waste materials to create sustainable and ecofriendly medical products.