Jun Young Ha, Jae Eun Kang, Yun Sik Yang
Focal laser photocoagulation was associated with regression of large, persistent PEDs, with responses influenced by lesion composition and neovascular activity. These preliminary findings require confirmation in larger controlled studies.
BACKGROUND AND OBJECTIVE: This study aimed to describe outcomes of focal laser photocoagulation for large, persistent pigment epithelial detachment (PED).
PATIENTS AND METHODS: Ten eyes underwent focal 577-nm yellow laser photocoagulation at the peripheral PED margin and were reviewed for 6 months, longer when available.
RESULTS: Eight eyes achieved complete PED regression within 6 months: four predominantly serous, two mixed serous-fibrovascular with inactive type 1 choroidal neovascularization (CNV), and two with polypoidal choroidal vasculopathy. In mixed and polypoidal lesions, regression predominantly involved the serous component. The mean time to regression was 2.5 months, and best-corrected visual acuity improved from 0.41 to 0.25 logMAR. Two eyes with active type 1 CNV showed incomplete responses. Seven eyes maintained regression over a mean 49.9-month follow-up. No laser-related complications occurred.
CONCLUSION: Focal laser photocoagulation was associated with regression of large, persistent PEDs, with responses influenced by lesion composition and neovascular activity. These preliminary findings require confirmation in larger controlled studies.