: Real-World Cases Using Phyto Polydeoxyribonucleotide (PDRN) Serum.

BACKGROUND: Integrative skincare refers to a clinician-directed regimen that combines aesthetic procedures with appropriate post-procedure skincare. The novel phyto polydeoxyribonucleotides (PDRN) formulation combines the benefits associated with the antioxidant, soothing phyto botanical blend with the effects of PDRN, a regenerative ingredient for wound-healing with collagen-stimulating properties. The serum contains an 8% phyto botanical complex, ectoin, tripeptide-8, and a 9.7% hydrating complex (glycerin and hyaluronic acid), along with PDRN derived from Lactobacillus sakei, a bacterium isolated from the soil of fallen magnolia flowers. Together, these components are designed to reduce immediate post-procedure redness and erythema while providing skin-rejuvenating benefits with continued use. METHODS: Nine global expert medical doctors share their experience incorporating the serum into post-procedure care with the goal of optimizing patient outcomes and minimizing downtime. The phyto PDRN serum was evaluated in a split-face real-world protocol for post-procedure care. RESULTS: Eight cases were selected by the expert panel to demonstrate the use of the phyto PDRN serum in an integrative skincare treatment plan under real-world conditions. All cases demonstrated successful integration of the phyto PDRN serum into the post-procedure care of eight women with Fitzpatrick skin types II–IV and aged from 28 to 68. Patients underwent non-ablative fractional laser, Nd:YAG, microneedling, microneedling radiofrequency, and chemical peels to address their various skin concerns. CONCLUSION: The phyto PDRN serum was safe, well-tolerated, and a clinically useful adjunct to integrative skin care regimens following cosmetic procedures. The antioxidant and anti-inflammatory ingredients, combined with PDRN polymers, uniquely support post-procedure recovery and skin repair.