Stefania Lamponi, Roberta Barletta, Annalisa Santucci
Agricultural and agro-industrial residues are increasingly recognized as sustainable, low-cost feedstocks for high-performance biomedical materials. This review critically examines the translational potential of polysaccharides, proteins, inorganic compounds, and phytochemical-rich extracts derived from agro-waste, highlighting their chemical features, structure-function relationships, and application-specific readiness. Polysaccharides such as nanocellulose, pectin, and chitosan emerge as the most advanced biopolymer platforms, particularly in wound healing, drug delivery, and 3D-printed scaffolds. Protein-derived materials-including collagen, gelatin, keratin, and soy protein-show strong promise in regenerative medicine, though challenges in mechanical stability and batch reproducibility remain. Inorganic phases such as hydroxyapatite and silica obtained from eggshells, rice husk ash, and marine shells demonstrate high bioactivity, with dental and bone applications approaching clinical translation. Finally, fruit-residue phytochemicals provide multifunctional antioxidant and antimicrobial enhancements to composite systems. By integrating material chemistry, processing strategies, and translational considerations, this review outlines the current state, challenges, and future perspectives for advancing agro-waste-derived biomaterials within a circular bioeconomy.