Renning Dong, Shuxin Shen, Yuhao Yang
Against the backdrop of global economic digital transformation and the rapid flow of creative factors, innovation spaces, as the key carriers of inventive activities, drive high-quality development in urban agglomerations. This study develops a three-dimensional framework of “Spatial Structure–Factor Synergy–Institutional Drivers” to uncover the evolution of innovation spaces and industrial shifts in the Beijing–Tianjin–Hebei urban agglomeration, China. Methodologically, spatial econometric techniques were applied to capture both the overall concentration and spatial disparities of innovation. Spatial Gini and variation coefficients measured innovation clustering, while standard deviation ellipses and location entropy identified spatial linkages among high-tech innovation clusters. Geographically weighted regression models explored spatial heterogeneity in influencing factors, and a policy intensity index was constructed to assess the effectiveness of differentiated policy interventions in optimizing innovation resources. Key findings include the following: (1) Innovation spaces are spatially polarized in a “core–periphery” pattern, yet require cross-regional collaboration. Concurrently, high-tech industries demonstrate a gradient structure: central cities leading in R&D, sub-central cities driving industrial applications, and node cities achieving specialized development through industrial transfer. (2) The driving mechanisms exhibit significant spatial heterogeneity: economic density shows diminishing returns in core areas, whereas R&D investment and ecological quality demonstrate increasingly positive effects, with foreign investment’s role evolving positively post-institutional reforms. (3) Regional innovation synergy has formed a preliminary framework, but strengthening sustainable policy mechanisms remains pivotal to advancing market-driven coordination and dismantling administrative barriers. These findings underscore the importance of integrated policy reforms for achieving balanced and high-quality innovation development in administratively coordinated urban agglomerations like BTH.