Jiandong Tang, Hebin Shen, Wenyu Lv, Jingxuan Zhang, Junsheng Fu
Natural melanin biopolymers exhibit a variety of biological activities, but their commercial development is constrained by numerous factors, including high costs, unsustainable sources, the use of harmful solvents during extraction, and low extraction efficiency. Notably, existing research indicates that synthetic melanin differs from natural melanin in nature, and this difference may directly impact its application efficacy. Additionally, the extraction process itself is highly challenging, primarily due to the diversity and complexity of melanin biopolymer structures. The melanin produced by edible fungi primarily belongs to the eumelanin category. Given its outstanding sustainability and accessibility, it is regarded as an ideal raw material for industrial production. To deepen our understanding of edible fungus-derived melanin and promote its effective application across various fields, a comprehensive review of research on melanin isolated from edible fungi is urgently needed. Such a review will help researchers from different disciplinary backgrounds recognize the importance of edible fungus melanin and provide reference information for their research planning. With this objective in mind, this report reviews the latest research progress in recent years regarding extraction methods, structural characterization, biological activity, and application areas of edible fungus-derived melanin. Additionally, the report explores key characteristic parameters for distinguishing different types of melanin and emphasizes the importance of deepening our understanding of the biosynthetic mechanisms of edible mushroom melanin, aiming to lay the foundation for its efficient production and application in the future.