Three-Dimensional Thoracic Aortic Remodeling Associated with Kommerell Diverticulum Enlargement in Adults with a Right-Sided Aortic Arch: A Quantitative CTA Study.

BACKGROUND: Right-sided aortic arch with Kommerell diverticulum (RAA-KD) has complex three-dimensional anatomy. METHODS: We retrospectively analyzed computed tomography angiography data from 65 adults with RAA-KD using centerline-based reconstruction. Patients were stratified by conventional maximal KD diameter (DKDmax) into <55 mm (n = 38) and ≥55 mm (n = 27) groups. Age associations, adjusted group differences, and continuous associations with centerline-derived KD diameter at maximal cross-sectional area (D10) were examined. RESULTS: After sex adjustment and false-discovery-rate correction, all aortic diameters increased with age; the ascending aorta, arch, and descending thoracic aorta also elongated, whereas aortic isthmus (L4) and KD (L5) lengths were not age-associated. After age and sex adjustment and false-discovery-rate correction, diameters of the ascending aorta, aortic arch, and descending thoracic aorta (D2-D8), as well as KD-related diameters (D9-D12), remained larger in the ≥55 mm group; L4 was shorter and L5 longer. In continuous models, D10 was positively associated with all non-KD diameters, most strongly with the adjacent proximal descending aorta (D7), and independently associated with shorter L4 (B = -0.548; 95% CI, -0.828 to -0.268) and longer L5 (B = 0.639; 95% CI, 0.412-0.866; both p < 0.001). CONCLUSIONS: RAA-KD demonstrates generalized age-associated thoracic aortic enlargement and localized KD-associated remodeling. Comprehensive three-dimensional assessment may inform evaluation of the adjacent aorta and proximal sealing zone for thoracic endovascular aortic repair.