Olga Evgenevna Voronko, Vitalia Sergeevna Novikova, Olesya Olegovna Klychkova, Margarita Pavlovna Markina, Arthur Anatolievich Lee, Dmitry Alexandrovich Kashirskikh, Victoria Alexandrovna Khotina, Vagif Ali Oglu Gasanov
This review summarizes current knowledge on the role of human cathelicidin LL-37 in the regulation of apoptosis. LL-37 can modulate programmed cell death pathways, exerting either proapoptotic or antiapoptotic effects depending on various factors, such as cell type and peptide concentration. Data on LL-37 derivatives and their involvement in apoptosis are also discussed. Understanding the molecular mechanisms underlying LL-37 regulation of apoptosis is necessary to expand the therapeutic potential of this peptide in various pathological conditions, including cancer.