Trends in Low Bone Density-Related Fall Burden and Mendelian Randomization Evidence on Waist Circumference and Bone Density - China, 1990-2023.

WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: Low bone mineral density increases fall risk in older adults; however, the age-specific effects of abdominal obesity remain unclear. WHAT IS ADDED BY THIS REPORT?: In China, from 1990 to 2023, deaths due to low bone density-related falls and disability-adjusted life-years increased by 3.66-fold and 3.01-fold, respectively. Mendelian randomization analysis suggested an inverse association between genetically predicted waist circumference and bone density in the 30-44- and ≥60-year groups. WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: Age- and sex-specific bone health screenings and weight-related metabolic management may help reduce the low bone density-related fall burden.