Mapping Bacteriophage-Based Antimicrobial Research in Southeast Asia: A Bibliometric Analysis of Scientific Productivity, Knowledge Structure, and Emerging Research Pathways.

Southeast Asia faces a substantial burden of antimicrobial resistance (AMR), creating increasing interest in bacteriophage-based antimicrobial strategies. However, the regional development, contributors, collaboration patterns, and evolving research priorities of this field remain insufficiently characterized. This study conducted a bibliometric analysis of Scopus-indexed publications on bacteriophage-based antimicrobial research affiliated with Southeast Asian countries from 1981 to 2025. Bibliometrix/Biblioshiny and VOSviewer were used to evaluate scientific production, citation patterns, leading contributors, collaboration networks, and conceptual and thematic development. A total of 862 publications were analyzed, with scientific output accelerating markedly after 2019 and reaching its highest level in 2025. Thailand emerged as the dominant regional contributor, with Vongkamjan (n = 21) and Surachat (n = 20) as the two most prolific authors. Mahidol University (n = 182), Prince of Songkla University (n = 142), and Universiti Putra Malaysia (n = 139) were the leading institutions, demonstrating a concentration of research capacity in Thailand and Malaysia. Scientific Reports was the most productive journal (30 publications), whereas Frontiers in Microbiology recorded the highest citation count among the leading sources (963 citations). Collaboration mapping revealed increasingly interconnected regional and international research networks. Thematic analyses demonstrated a transition from foundational and pathogen-specific investigations toward AMR, bacteriophage therapy, biofilm control, aquaculture, genomic and comparative genomic analysis, wastewater and public-health applications, and One Health-oriented research. Emerging topics included endolysins, quorum sensing, CRISPR-associated approaches, metagenomics, and genome-informed phage characterization. These findings demonstrate the rapid expansion and thematic diversification of bacteriophage-based antimicrobial research in Southeast Asia while highlighting persistent geographic concentration and the need for stronger regional infrastructure, collaboration, and translational capacity.