Michalis A. Savelonas
Accurate segmentation and analysis of thyroid nodules in ultrasound (US) images are essential for the diagnosis and management of thyroid conditions, including cancer. Despite advancements in medical imaging, achieving accurate and efficient segmentation remains a significant challenge due to the complexity and variability of US images. Recently, deep learning (DL) techniques, such as convolutional neural networks (CNNs) and vision transformers (ViTs), have emerged as powerful tools for computer-aided diagnosis (CAD). This review highlights recent advancements in thyroid US image segmentation, focusing on state-of-the-art DL techniques such as contrastive learning, consistency learning, and knowledge-driven DL. We explore various approaches to improve segmentation accuracy, including multi-task learning, self-supervised learning, and methods that minimize reliance on the availability of large, annotated datasets. Additionally, we examine the clinical significance of these methods in differentiating between benign and malignant nodules, as well as their potential for integration into clinically adopted, fully automated CAD systems. By addressing the latest developments and ongoing challenges, this review serves as a comprehensive reference for future research and clinical implementation of thyroid US diagnostics.