Artificial Intelligence-Based Epileptic Seizure Prediction Strategies: A Review

Epilepsy, a chronic neurological disorder marked by recurrent and unpredictable seizures, poses significant risks of injury and compromises patient quality of life. The accurate forecasting of seizures is paramount for enabling timely interventions and improving safety. Since the 1970s, research has increasingly focused on analyzing bioelectrical signals for this purpose. In recent years, artificial intelligence (AI), particularly machine learning (ML) and deep learning (DL), has emerged as a powerful tool for seizure prediction. This review, conducted by PRISMA guidelines, analyzes studies from 2020 to August 2025. It explores the evolution from traditional ML classifiers toward advanced DL architecture, including convolutional and recurrent neural networks and transformer-based frameworks, applied to bioelectrical signals. While these approaches show promising performance, significant challenges persist in patient generalization, standardized evaluation, and clinical validation. This review synthesizes current advancements, provides a critical analysis of methodological limitations, and outlines future directions for developing robust, clinically relevant seizure prediction systems to enhance patient autonomy and outcomes.