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◆ Frontiers in Pharmacology2025-11-05· Polysaccharide

Recent advances in Bletilla striata polysaccharide research: extraction methodologies, structural elucidation, pharmacological mechanisms, structure–activity relationships, and therapeutic delivery applications

Bo Wang, Chaomeng Wu, Yaohong Ma, Xiaofen Liu, Lijun Tao, Xuebing Zhou, Lin Jia

原始摘要(英文原文)· Original abstract
polysaccharide (BSP), is a water-soluble heteropolysaccharide composed primarily of mannose and glucose. Various extraction techniques-including hot water, ultrasonic assisted, and microbial fermentation methods-have been developed to isolate BSPs, with extraction parameters significantly influencing its structural features. BSPs exhibit diverse pharmacological activities, such as wound healing, immunomodulation, anti-inflammatory, antioxidant, and gut microbiota regulatory effects. Despite extensive studies, the structure-activity relationships (SARs) and toxicological profile of BSPs remain incompletely understood. Owing to its favorable biodegradability and biocompatibility, BSPs show promise as a nanocarrier for drug delivery. This review summarizes advanced purification and structural characterization techniques, pharmacological mechanisms, potential toxicities, and drug delivery applications of BSPs, providing a translational framework for future research and development.
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Recent advances in Bletilla striata polysaccharide research: extraction methodologies, structural elucidation, pharmacological mechanisms, structure–activity relationships, and therapeutic delivery applications — 科研速览 Science Skim