Pengcheng Li, Jirui Cai, Shuaifang Yuan, Yapeng Li, Huiting Shi, Cui Liang, Bing He, Qiaotao Xie, Baocang Lei, Jing Bai, Nan Wang, Dongliang Liu, Qichao Wang, Jianwei Xiong, Jin Wang, Haoran Wang
Aims: The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio reflects the balance between atherogenic and anti-atherogenic lipid fractions. The study aims to investigate the utility of the TG/HDL-C ratio in identifying high-risk groups for cardiovascular disease (CVD) within the general population. Methods: The current study was a branch of the ChinaHEART cohort in middle China that involved a total of 6,593 community-dwelling adults. We examine the association between TG/HDL-C and CVD high-risk in a cross-sectional investigation. Results: Results from restricted cubic spline and ROC analyses revealed a significant relationship between higher TG/HDL-C levels and increased odds of CVD high-risk, with the ratio exhibiting good discriminatory power (AUC = 0.820 in the fully adjusted model). Logistic regression further supported this association, indicating a 1.21-fold rise in the odds of high risk for each unit increase in TG/HDL-C. Conclusions: The TG/HDL ratio shows promise for CVD risk assessment. Incorporating the TG/HDL ratio into risk assessment models may provide supplementary information to healthcare professionals for risk stratification.