Association between triglyceride glucose-body mass index and clinical outcomes after septal myectomy.

AIMS: This study examined the association between triglyceride glucose-body mass index (TyG-BMI) and clinical outcomes in patients with hypertrophic obstructive cardiomyopathy (HOCM) undergoing septal myectomy. METHODS: This retrospective cohort study was conducted at Fuwai Hospital, including 1,302 patients with HOCM who underwent septal myectomy. According to the tertile distribution of TyG-BMI, the participants were classified into three groups (T1-T3). The primary endpoint consisted of heart failure hospitalization or all-cause death. RESULTS: The mean age of the participants was 49.2 ± 11.8 years, of whom 61% (791) were men. During a median follow-up of 4.3 (3.1-6.2) years, the cumulative incidences of primary endpoint and all-cause death differed significantly across the three groups on the Kaplan-Meier analysis (log-rank P < 0.05). Cox analysis showed that patients in group T3 exhibited the greatest incidence rates of primary endpoint (adjusted hazard ratio (HR) = 2.00, 95% confidence interval (CI) 1.16-3.44, P = 0.012) as well as the highest risk of all-cause death (adjusted HR = 3.39, 95% CI 1.34-8.58, P = 0.010) compared to those in group T1. When treated as a continuous variable, TyG-BMI remained significantly linked to an elevated risk of primary endpoint (adjusted HR = 1.007, 95% CI 1.002-1.012, P = 0.009) and increased all-cause death (adjusted HR = 1.013, 95% CI 1.006-1.021, P = 0.001). CONCLUSIONS: Higher TyG-BMI was associated with an increased risk of adverse long-term outcomes after septal myectomy in patients with HOCM.