Fatma Nur Cicin, Güney Çetin Gürkan
Objective This study investigates the factors influencing physicians’ acceptance and adoption of artificial intelligence (AI) technologies in clinical practice, integrating the Theory of Planned Behavior (TPB) and the Technology Acceptance Model (TAM), while also examining the mediating role of trust. Methods A structured survey was conducted among 414 physicians assessing their perceptions of AI technologies using constructs from TPB, TAM, and trust-related factors. Partial Least Squares Structural Equation Modeling (PLS-SEM) was employed for data analysis. Results Findings confirm that TPB and TAM effectively explain physicians’ AI acceptance, with TPB exhibiting a stronger predictive power compared to TAM. Trust emerged as a critical determinant in AI adoption, fully mediating the relationship between perceived behavioral control ( p < 0.001), subjective norms ( p < 0.05), perceived usefulness ( p < 0.001), ease of use ( p < 0.001), and behavioral intention. Notably, perceived ease of use ( p < 0.001) had the strongest direct impact on trust, while perceived usefulness ( p < 0.001) significantly influenced behavioral intention. Attitude toward AI showed a significant effect ( p < 0.01). Subjective norms and perceived behavioral control had weaker direct influences ( p < 0.05 and p = 0.07, respectively). Conclusion Trust plays a pivotal role in AI adoption, shaping physicians’ acceptance beyond traditional TPB and TAM factors. Healthcare administrators, policymakers, and technology developers should focus on enhancing trust by improving AI transparency, interpretability, and user-friendly design.