Xinmeng Yang, Xiaoling Yu, Shuiwei Qiu
This review synthesizes the current state of knowledge on medical-coating materials. Fundamental theories are examined with respect to material taxonomy, physicochemical properties, biocompatibility profiles, and antimicrobial mechanisms. Clinical applications are reviewed for implants, wound dressings, catheters, and endovascular stents. Technological advances are highlighted in nanotechnology, surface-modification strategies, and the development of stimulus-responsive "smart" coatings. The analysis traces the field's evolution, noting its growing market and clinical adoption, while identifying persistent challenges in long-term biosafety and translation. Future directions are projected toward synergistic modification for multifunctionality, patient-specific designs, and next-generation intelligent systems. By integrating contemporary research, this review aims to inform and guide the future development and clinical application of advanced coating technologies.