Jaya Rajkumar Ramchandani, Suddhasheel Ghosh
Introduction Urban flyover infrastructure requires balancing structural efficiency, cost minimization, and environmental sustainability. Traditional deterministic methods fail to capture variability and reproducibility in large-scale civil projects. Methods A comprehensive framework was developed integrating Radial Basis Function (RBF) surrogate modeling, sensitivity and uncertainty analysis, and comparative evaluation of nine optimization algorithms (NSGA-II, NSGA-III, DE, CMA-ES, GA, ES, SRES, Nelder-Mead, Pattern Search). The dataset included 47 flyover configurations across 12 Indian cities. Results The RBF surrogate reduced computational effort by 95–98% while maintaining predictive accuracy (R 2 > 0.95). Application to the Aurangabad interlinking flyover project achieved cost savings of 8–12%, environmental impact reductions of 15–25%, and material efficiency improvements of 20–30%. Soil bearing capacity and traffic volume accounted for 58% of cost variance. Discussion The integration of surrogate modeling and multi-algorithm optimization advances sustainable infrastructure design by providing robust, reproducible, and evidence-based solutions. This framework demonstrates practical relevance for balancing economic viability, structural adequacy, and environmental responsibility in urban flyover development.