Mohammad Nazmul Hasnine Nawshad, Md Khairul Anam, Nihar Ranjan Saha, Romana Afaz Ireen, Md Mamun Or Rashid, Md Habibur Rahman, HM Aminur Rashid, Nirmal Kanti Sarker, Muhammad Humayoun Kabir, Md Abdul Mannan, Goutam Sen
Background: Sequential Organ Failure Assessment (SOFA) score was designed for describing the severity of a patient’s illness resulted from the affected degree of six organ failure or dysfunction, There was little knowledge about application of SOFA scoring system to predict weanability from mechanical ventilation. Aims: The aim of the study was to determine the SOFA score as a predictive index for weaning of the patients from mechanical ventilation. Materials & Methods: This prospective observational study conducted at the Department of Respiratory Medicine in National Institute of Diseases of the Chest and Hospital (NIDCH) from March 2020 to February 2021 in collaboration with the Department of Respiratory Intensive Care Unit (ICU). A total of 42 critically ill patients admitted to Respiratory ICU of NIDCH were enrolled in this study. SOFA score measured every day and weaning process involved spontaneous breathing trial with a T piece. Statistical analyses of the results were obtained by using windows based computer software devised with Statistical Packages for Social Sciences (SPSS-23). Results: Among the 42 patients with a mean age of 58.5±18.6 years requiring MV, 34(81%) patients were successfully weaned from Mechanical Ventilation. Male patients were predominant 39(92.9%) with male to female ratio was 13:1.The most common reason for ICU admission was acute exacerbation of COPD (AECOPD) with Type 2 Respiratory Failure 7(16.7%). Fifty seven percent patients had DM followed by 21(50.0%) HTN. Among 42 patients, 8(19.0%) patients were died and 31(73.8%) were survived. The mean SOFA score maximum was found 8.0±2.0 with range from 5 to 14. Based on the receiver-operator characteristic (ROC) curves SOFA score maximum had area under curve 0.991. Receiver-operator characteristic (ROC) was constructed by using SOFA score level, which gave a cut off value ³9.5 with 87.5% sensitivity and 97.1% specificity for prediction of mortality. With cut off SOFA score ³9.5 mean duration of mechanical ventilation was 6.8±3.3 days. There were no significant association of socio-demographic variables and co-morbidities compared with successful weaning and weaning failure patients. Conclusion: In conclusion, SOFA score may be used as predictive index for weanability from mechanical ventilation. Chest Heart J. 2022; 46(1) : 3-9