Pierina D'Angelo, Lieska Rodríguez, Víctor Alarcón, Yoneira Sulbarán, Norca García, Giulianna Antonelli, Marwan Aguilar, Martha Bravo, Zoila C Moros, Carmen L Loureiro, Ferdinando Liprandi, José L Zambrano, Rossana C Jaspe, Flor H Pujol
We describe 5 cases of human Oropouche virus infection detected in rural Venezuela in 2025. All isolates belonged to the OROVBr2015-2024 reassortant lineage linked to the 2024-2025 epidemic. Our results emphasize ongoing transmission, which highlights the need for strengthened surveillance and laboratory capacity in South America.