Association Between Sleep Duration and Hypertension Development in Women: A Meta-Analysis.

This study examined the association between females' sleep duration and the development of hypertension (HTN). Searches were conducted in Embase, PubMed, Cochrane Library, Web of Science, CNKI, VIP, and Wanfang databases up to March 15, 2024. Using RR as the effect measure, the combined RR and 95% CI were calculated using Stata 15.0. A total of 10 articles, comprising 12 cohort studies, were included in the meta-analysis. Inadequate sleep duration is associated with HTN in women (RR: 1.10, 95% CI: 1.06-1.13, p <0.001). However, long sleep duration was not associated with HTN in women (RR: 1.00, 95% CI: 0.96-1.05, p = 0.958). Short- and long-sleep duration groups showed no publication bias. Subgroup and meta-regression analyses indicated that age and variation in the operational definition of sleep duration were the principal sources of heterogeneity. In age-stratified analysis, both <50 years (RR = 1.19, 95% CI: 1.11-1.28, p <0.001) and ≥50 years (RR = 1.06, 95% CI: 1.00-1.12, p = 0.036) showed increased HTN risk among women with short sleep duration. The dose-response association was L-shaped; using 4 hours/day as the reference, the lowest risk was observed at approximately 7.5 hours/day. For women, insufficient sleep duration is linked to a higher risk of developing HTN. Key Words: Hypertension, Women, Sleep duration, Prospective cohort study, Meta-analysis.