Syakinah Anian, Aidalina Mahmud, Anita Abd Rahman, Mohamad Fadli Kharie, M A Omar
Background: Weak governance of hospital information systems interoperability can impede data accuracy, security and accessibility. Aim: To review and synthesise published literature on governance of hospital information systems interoperability. Methods: Using the preferred reporting Items for systematic reviews and meta-analyses method, we reviewed on Scopus, PubMed and ScienceDirect literature on governance of hospital information systems interoperability published between June 2014 and June 2024, across Africa, Asia, Americas, Middle East, Europe, and Oceania. Results: The key governance strategies are classified into 3: policy and regulation, standards and frameworks, and sustainable funding and resources. Policies and regulations governing hospital information systems interoperability are typically established at national, regional and organisational levels to safeguard patient data privacy. Interoperability frameworks typically address system structures, core functions and interoperability standards, while some also incorporate access to open-source digital tools. Human and technical resources are often recognised as influential and essential factors for efficient interoperability. Conclusion: Effective governance is essential for building and operating integrated interoperable hospital information systems as well as for improving efficiency, optimising resource use and advancing health outcomes.