Naveena Poudyal
Azole are first line drugs used for treatment of most fungal infection. Resistance towards azole based drugs are rapidly increasing. Chemical modification of kanamycin creates promising class of antifungal compounds against both human and crop pathogenic fungi. Based on the structure of commonly available azole antifungals, a library of kanamycin-azole hybrids are synthesized, and their antifungal activities are studied. The lead hybrids are active against resistant C. albicans, C. tropicalis and C. neoformans strains. Early and accurate diagnosis is crucial for timely and effective treatment of fungal infections. Fluorescence based small molecules has the potential for rapid detection by enabling real-time imaging and quantification of fungal cells. A library of fluorescent kanamycin probe are synthesized and tested against various fungal strains. Strain dependent relative fluorescence intensity and unique fluorescence profile were obtained from the synthesized probes.