Design, synthesis and biological evaluation of novel N-napthyl-5-aryl-1,3,4-thiadiazol-2-amine derivatives as anticancer and their molecular docking studies

A novel series of N-napthyl-5-aryl-1,3,4-thiadiazol-2-amine derivatives have been synthesized from naphthyl-thiosemicarbazide and carboxylic acids using intermolecular cyclization under acidic condition. The newly synthesized compounds have been characterized by IR, 1H, 13C NMR and mass spectral studies. All the synthesized compounds subjected to comprehensive analysis of their in vitro anticancer against human prostate carcinoma cell line (PC-3). Amongst, compound 3d exhibited prominent cytotoxicity activity towards prostate cancer cell line (PC-3 cell: IC50 = 26.95±0.06 μM), comparable to doxorubicin. Our finding provides a new structure of thiadiazole having promising potential in anticancer drug development program.