Chlorogenic acid supplementation regulates redox status, hepatic inflammation, and mitochondrial function in weaned piglets with intrauterine growth retardation

The present study aimed to explore the effect of dietary microbe-derived antioxidants (MA) supplementation on plasma biochemical parameters, oxidative stress and fecal microbiota in Beagles dogs. Results showed that different dose of MA supplementation did not affect body weight (BW) of dogs after 30 days feeding. 1.5 g/kg MA (HMA) treatment decreased the content of plasma total antioxidant capacity (T-AOC) and activities of aspartate aminotransferase (AST) and lactate dehydrogenase (LDH), increased contents of malondialdehyde (MDA), total cholesterol (T-CHO), total protein (TP) and creatine kinase MB (CKMB) compared with control (CON) group. 1 g/kg MA (MMA) decreased the content of triglyceride (TG), and activity of plasma AST compared with CON group at day 30 (D30). 0.5 g/kg MA (LMA) decreased the contents of malondialdehyde (MDA) at day 14 (D14) and T-AOC at day 7 (D7), and T-CHO at D14 and D7 compared with CON group. Furthermore, in HMA, activities of alanine aminotransferase (ALT) and AST, contents of T-AOC, T-CHO, urea nitrogen (BUN) and direct bilirubin (DBil) decreased at D30 compared with D14 and D7. Consumption of HMA increased the fecal bacterial evenness and modulated microbial profiles at D14 compared with D7. Taken together, appropriate supplementation of MA is a promising candidate to improve nutrients metabolism, hepatic function and fecal microbiota in beagle dogs.