Justin H M Yung, Emily G Hoffman, Aleksandar Ivovic, S M Niazur Rahman, Tejas Desai, Khajag Koulajian, Yusaku Mori, Charles Maisonneuve, Marry Nissan, Ayse Bengisu Gelmez, Yasmin Rabiee, Sandra Pereira, Dana Al-Rijjal, Michael B Wheeler, Dana J Philpott, Adria Giacca, Kacey J Prentice
The innate immunity receptor nucleotide-binding oligomerization domain 1 (Nod1) can be activated by saturated fatty acids and is implicated in high-fat diet-induced inflammation and insulin resistance. This implies Nod1 plays a role in glucose homeostasis; therefore, we sought to determine whether saturated fatty acids cause pancreatic β-cell dysfunction through Nod1. Our data demonstrate that Nod1 is involved in palmitate-induced β-cell dysfunction in vitro and in vivo.