Pharmacovigilance Knowledge, Attitudes, and ADR Reporting Behaviour Among Physicians and Pharmacists in a Tertiary Hospital.

INTRODUCTION: Adverse Drug Reactions (ADRs) remain a major challenge in pharmacovigilance due to persistent underreporting. Healthcare professionals' knowledge, attitudes, and reporting practices play an important role in effective ADR monitoring. This study aimed to assess pharmacovigilance knowledge, attitudes, and ADR reporting behaviour among physicians and pharmacists and to identify factors associated with ADR reporting. METHODS: This cross-sectional study was conducted among physicians and pharmacists in a tertiary hospital in Türkiye between August 2024 and September 2025. A structured questionnaire was used to assess pharmacovigilance knowledge, attitudes, and ADR reporting behaviour. ADR reports from the institutional system over the past five years were also reviewed. Knowledge scores were calculated as the proportion of correct answers. Associations between variables were analyzed using independent-samples t-test and chi-square test. Statistical significance was set at p < 0.05. RESULTS: A total of 224 healthcare professionals participated (196 physicians, 28 pharmacists). Pharmacists had significantly higher knowledge scores than physicians (p < 0.001). However, previous ADR reporting was uncommon in both groups, with similar reporting rates among physicians (22/196, 11.2%) and pharmacists (3/28, 10.7%). Previous pharmacovigilance training was significantly associated with previous ADR reporting in bivariate analysis, whereas professional experience was not. In multivariable logistic regression, pharmacovigilance knowledge score was independently associated with previous ADR reporting. DISCUSSION: Pharmacists demonstrated higher pharmacovigilance knowledge than physicians; however, this advantage did not translate into ADR reporting rates. The findings indicate that improving knowledge alone may not be sufficient, and institutional support and targeted training strategies are required to enhance reporting behaviour. CONCLUSION: Knowledge gaps and limited awareness remain important challenges in ADR reporting. Although pharmacists had higher pharmacovigilance knowledge, reporting rates were similar between groups. Targeted training programs may contribute to improving ADR reporting practices.