Kohei Kiso, Yusuke Shimoyama, Saki Okuda-Hiwatashi, Taku Fujimura, Yoshihide Asano, Rui Makino, Tetsuhiro Tanaka, Hideya Iwaki, Daisuke Okamoto, Hiroshi Nagai, Takeo Naito, Rintaro Moroi, Yoichi Kakuta, Atsushi Masamune
Cronkhite-Canada syndrome (CCS) is a rare disorder characterized by gastrointestinal polyposis and ectodermal abnormalities. We report the case of a 64-year-old man with CCS complicated by primary cutaneous peripheral T-cell lymphoma (PC-PTCL) and membranous nephropathy. Cutaneous lymphoma was controlled using topical corticosteroids and phototherapy. During the clinical course of CCS, the patient developed proteinuria, and a renal biopsy revealed membranous nephropathy with equivocal phospholipase A2 receptor staining. Corticosteroid therapy improved both the gastrointestinal manifestations and proteinuria. This case suggests a possible immune-mediated association among CCS, PC-PTCL, and membranous nephropathy.