Takaya Suzuki, Mai Ishikawa, Takuya Yamaguchi, Masahiro Miyata, Takaaki Nawano, Yukino Yokokawa, Soichiro Kon, Eri Matsuki, Sayumi Watanabe, Keita Kamei, Kazunobu Ichikawa, Masafumi Watanabe
Scleroderma renal crisis (SRC) and posterior reversible encephalopathy syndrome (PRES) are rare but severe complications of systemic sclerosis (SSc). We report the case of a 44-year-old patient with SSc who developed SRC and PRES, potentially triggered by non-steroidal anti-inflammatory drugs (NSAIDs). The patient presented with impaired consciousness, renal dysfunction, hemolytic anemia, thrombocytopenia, and occipital white matter lesions on magnetic resonance imaging. Treatment included enalapril, hemodialysis, and plasma exchange. This case highlights the potential role of NSAIDs in the development of SRC, and emphasizes the importance of considering NSAIDs as a significant risk factor for SRC in patients with SSc.