Summary of Best Evidence for the Management and Recurrence Prevention of Febrile Seizures in Children

Objective: This study aims to systematically search, screen, evaluate, and summarize the best evidence related to the prevention and management of febrile seizures in children, with the goal of providing evidence-based guidance for clinical practice in this field. Methods: A comprehensive search was conducted across multiple databases, including UpToDate, Joanna Briggs Institute (JBI), Guidelines International Network, Agency for Healthcare Research and Quality, Scottish Intercollegiate Guidelines Network, National Institute for Health and Care Excellence, Registered Nurses Association of Ontario, the Cochrane Library, Embase, PubMed, Web of Science, China National Knowledge Internet (CNKI), SinoMed, and WanFang database. The search deadline was from database establishment to July, 2025. Two researchers independently evaluated the quality of the included literature and extracted and summarized the evidence. Results: Twenty literature sources were included, comprising 3 clinical decision, 7 guidelines, 4 expert consensus, 1 best practice, and 5 systematic reviews. Through integration of these sources, 29 best evidence statements were ultimately developed, covering 6 major themes: Clinical assessment and diagnosis, Indications of hospitalization, risk assessment, non-pharmacological treatment, pharmacological treatment, as well as caregiver support and follow-up. Conclusion: This study summarizes the best evidence for the prevention and management of febrile seizures in children. In clinical application, healthcare professionals should make professional judgment and select evidence based on clinical circumstances and the preferences of the child, thereby providing a more scientifically grounded basis for clinical nursing practice. Trial and Protocol Registration: This study was based on the evidence summary reporting specifications of the Fudan University Center for the Evidence-based Nursing, the register name is "Evidence summary for prevention and management of febrile seizures in children", the registration number is "ES20246803".