Xi Chen, Wei Zhao, Beibei Yu, Yuge Liu, Yan Ma, Chi‐Tsai Tang, Yibo Huang, Ming Yan
Background and Aim: Postoperative delirium (POD) and emergence agitation (EA) are common complications in older patients undergoing video-assisted thoracoscopic surgery (VATS), significantly impacting recovery. This study was designed to examine whether remimazolam is noninferior to dexmedetomidine for preventing POD and EA in elderly patients following VATS. Patients and Methods: A total of 176 elderly patients scheduled for VATS due to lung cancer were randomly assigned to receive either dexmedetomidine (Group D, n = 88) or remimazolam (Group R, n = 88). Group D received dexmedetomidine at 0.5 μg/kg/h starting 3 minutes before anesthesia induction until surgery completion. Group R received remimazolam at 0.5 mg/kg/h over the same period. The primary outcomes were the incidence of EA and POD within 5 days after surgery. Secondary outcomes included Quality of Recovery-15 (QoR-15) score, Athens Insomnia Scale (AIS), and numeric rating scale (NRS) for pain. Correlations among hypotension, EA, and POD were also analyzed. Results: < 0.01), with overall rates of 20.73% vs 18.75% and 10.98% vs 8.75%, respectively. No significant differences were observed in QoR-15 or NRS scores between groups, though Group D had lower AIS scores on postoperative day 1. Group R demonstrated more stable intraoperative hemodynamics with reduced requirements for opioids and vasopressors, and shorter extubation times. Hypotension and EA were significantly correlated with POD. Conclusion: Remimazolam was non-inferior to dexmedetomidine in preventing POD and EA in elderly patients undergoing VATS while providing improved hemodynamic stability and reducing the need for intraoperative opioids and vasopressors.